Heterogeneity among Viral Antigen-Specific CD4+T Cells and Their De Novo Recruitment during Persistent Polyomavirus Infection

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Heterogeneity among viral antigen-specific CD4+ T cells and their de novo recruitment during persistent polyomavirus infection.

Virus-specific CD4(+) T cells optimize antiviral responses by providing help for antiviral humoral responses and CD8(+) T cell differentiation. Although CD4(+) T cell responses to viral infections that undergo complete clearance have been studied extensively, less is known about virus-specific CD4(+) T cell responses to viruses that persistently infect their hosts. Using a mouse polyomavirus (M...

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Given the global impact of persistent infections on the human population, it is of the utmost importance to devise strategies to noncytopathically purge tissues of infectious agents. The central nervous system (CNS) poses a unique challenge when considering such strategies, as it is an immunologically specialized compartment that contains a nonreplicative cell population. Administration of exog...

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Viral microRNA effects on persistent infection of human lymphoid cells by polyomavirus SV40

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ژورنال

عنوان ژورنال: The Journal of Immunology

سال: 2010

ISSN: 0022-1767,1550-6606

DOI: 10.4049/jimmunol.0904210